Miguel A R B Castanho

Affiliations

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028, Lisboa, Portugal.

ORCID: http://orcid.org/0000-0001-7891-7562

Publications (36)

Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy.

Eye (London, England)

Avec: David Cordeiro Sousa , Inês Leal , Susana Moreira , Sónia do Vale , Ana R Silva-Herdade , Patrícia Dionísio , Miguel A R B Castanho , Luís Abegão Pinto , Carlos Marques-Neves

Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide.

Pharmaceutics

Avec: Marco Cavaco , Patrícia Fraga , Javier Valle , David Andreu , Miguel A R B Castanho , Vera Neves

Temperature-Dependent Re-alignment of the Short Multifunctional Peptide BP100 in Membranes Revealed by Solid-State NMR Spectroscopy and Molecular Dynamics Simulations.

Chembiochem : a European journal of chemical biology

Avec: Erik Strandberg , Parvesh Wadhwani , Jochen Bürck , Patrick Anders , Christian Mink , Jonas van den Berg , Raffaele A M Ciriello , Manuel N Melo , Miguel A R B Castanho , Eduard Bardají , Jakob P Ulmschneider , Anne S Ulrich

Resazurin Reduction-Based Assays Revisited: Guidelines for Accurate Reporting of Relative Differences on Metabolic Status.

Molecules (Basel, Switzerland)

Avec: Beatriz Vieira-da-Silva , Miguel A R B Castanho

Quantitative Imaging of the Action of vCPP2319, an Antimicrobial Peptide from a Viral Scaffold, against

ACS infectious diseases

Avec: Susana A Dias , Sandra N Pinto , Ana S Silva-Herdade , Marco Cavaco , Vera Neves , Luís Tavares , Manuela Oliveira , David Andreu , Ana Coutinho , Miguel A R B Castanho , Ana Salomé Veiga

Antifungal and anti-biofilm activity of designed derivatives from kyotorphin.

Fungal biology

Avec: Vitor Martins de Andrade , Eduard Bardají , Montserrat Heras , Vasanthakumar G Ramu , Juliana Campos Junqueira , Jéssica Diane Dos Santos , Miguel A R B Castanho , Katia Conceição

Plant defensin PvD

Nanoscale

Avec: Julia Skalska , Filipa D Oliveira , Tiago N Figueira , Érica O Mello , Valdirene M Gomes , Grant McNaughton-Smith , Miguel A R B Castanho , Diana Gaspar

Synthesis, Structure, and Activity of the Antifungal Plant Defensin

Journal of medicinal chemistry

Avec: Julia Skalska , Vitor M Andrade , Gabrielle L Cena , Peta J Harvey , Diana Gaspar , Érica O Mello , Sónia T Henriques , Javier Valle , Valdirene M Gomes , Katia Conceição , Miguel A R B Castanho , David Andreu

Structural determinants conferring unusual long life in human serum to rattlesnake-derived antimicrobial peptide Ctn[15-34].

Journal of peptide science : an official publication of the European Peptide Society

Avec: Clara Pérez-Peinado , Susana A Dias , Diogo A Mendonça , Miguel A R B Castanho , Ana S Veiga , David Andreu

Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity.

Biomacromolecules

Avec: Thais H Costa Petrin , Valmir Fadel , Danubia B Martins , Susana A Dias , Ana Cruz , Luciana Marciano Sergio , Manoel Arcisio-Miranda , Miguel A R B Castanho , Marcia P Dos Santos Cabrera

Lidocaine turns the surface charge of biological membranes more positive and changes the permeability of blood-brain barrier culture models.

Biochimica et biophysica acta. Biomembranes

Avec: Ana R Santa-Maria , Fruzsina R Walter , Sándor Valkai , Ana Rita Brás , Mária Mészáros , András Kincses , Adrián Klepe , Diana Gaspar , Miguel A R B Castanho , László Zimányi , András Dér , Mária A Deli

Effect of pH on the influenza fusion peptide properties unveiled by constant-pH molecular dynamics simulations combined with experiment.

Scientific reports

Avec: Diana Lousa , Antónia R T Pinto , Sara R R Campos , António M Baptista , Ana S Veiga , Miguel A R B Castanho , Cláudio M Soares

Mechanistic insights on the antibacterial action of the kyotorphin peptide derivatives revealed by in vitro studies and Galleria mellonella proteomic analysis.

Microbial pathogenesis

Avec: Vitor M de Andrade , Vitor D M de Oliveira , Uilla Barcick , Vasanthakumar G Ramu , Montserrat Heras , Eduard R Bardají , Miguel A R B Castanho , André Zelanis , Aline Capella , Juliana C Junqueira , Katia Conceição

Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation.

Fluids and barriers of the CNS

Avec: Marco Cavaco , Patrícia Fraga , Javier Valle , Ruben D M Silva , Lurdes Gano , João D G Correia , David Andreu , Miguel A R B Castanho , Vera Neves

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

Frontiers in pharmacology

Avec: Rita F Belo , Margarida L F Martins , Liana Shvachiy , Tiago Costa-Coelho , Carolina de Almeida-Borlido , João Fonseca-Gomes , Vera Neves , Hugo Vicente Miranda , Tiago F Outeiro , Joana E Coelho , Sara Xapelli , Cláudia A Valente , Montserrat Heras , Eduard Bardaji , Miguel A R B Castanho , Maria José Diógenes , Ana M Sebastião

Retinal Vascular Reactivity in Type 1 Diabetes Patients Without Retinopathy Using Optical Coherence Tomography Angiography.

Investigative ophthalmology & visual science

Avec: David Cordeiro Sousa , Inês Leal , Susana Moreira , Sónia do Vale , Ana S Silva-Herdade , Patrício Aguiar , Patrícia Dionísio , Luís Abegão Pinto , Miguel A R B Castanho , Carlos Marques-Neves

Design of bioactive peptides derived from CART sequence isolated from the toadfish

3 Biotech

Avec: Katia Conceição , Gabrielle L de Cena , Verônica A da Silva , Xisto Antonio de Oliveira Neto , Vitor Martins de Andrade , Dayane Batista Tada , Michael Richardson , Sonia A de Andrade , Susana A Dias , Miguel A R B Castanho , Mônica Lopes-Ferreira

A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography.

Frontiers in neuroscience

Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties.

ACS chemical biology

Avec: Grégoire J-B Philippe , Diana Gaspar , Caibin Sheng , Yen-Hua Huang , Aurélie H Benfield , Nicholas D Condon , Joachim Weidmann , Nicole Lawrence , Alexander Löwer , Miguel A R B Castanho , David J Craik , Sónia Troeira Henriques

Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein.

ACS infectious diseases

Avec: Iris Cadima-Couto , Alexandra Tauzin , João M Freire , Tiago N Figueira , Rúben D M Silva , Clara Pérez-Peinado , Catarina Cunha-Santos , Inês Bártolo , Nuno Taveira , Lurdes Gano , João D G Correia , Joao Goncalves , Fabrizio Mammano , David Andreu , Miguel A R B Castanho , Ana Salomé Veiga

Overlapping Properties of the Short Membrane-Active Peptide BP100 With (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides.

Frontiers in cellular and infection microbiology

Avec: Christian Mink , Erik Strandberg , Parvesh Wadhwani , Manuel N Melo , Johannes Reichert , Irene Wacker , Miguel A R B Castanho , Anne S Ulrich

Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity.

Bioconjugate chemistry

Avec: Diogo A Mendonça , Mariët Bakker , Christine Cruz-Oliveira , Vera Neves , Maria Angeles Jiménez , Sira Defaus , Marco Cavaco , Ana Salomé Veiga , Iris Cadima-Couto , Miguel A R B Castanho , David Andreu , Toni Todorovski

The Use of Antibody-Antibiotic Conjugates to Fight Bacterial Infections.

Frontiers in microbiology

Avec: Marco Cavaco , Miguel A R B Castanho , Vera Neves

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide-Porphyrin Conjugates.

Pharmaceutics

Avec: Toni Todorovski , Diogo A Mendonça , Lorena O Fernandes-Siqueira , Christine Cruz-Oliveira , Giuseppina Guida , Javier Valle , Marco Cavaco , Fernanda I V Limas , Vera Neves , Íris Cadima-Couto , Sira Defaus , Ana Salomé Veiga , Andrea T Da Poian , Miguel A R B Castanho , David Andreu

The structure and matrix dynamics of bacterial biofilms as revealed by antimicrobial peptides' diffusion.

Journal of peptide science : an official publication of the European Peptide Society

Avec: Beatriz Vieira-da-Silva , Miguel A R B Castanho

Current pharmaceutical design

Avec: Marco Cavaco , Javier Valle , Ruben da Silva , João D G Correia , Miguel A R B Castanho , David Andreu , Vera Neves

The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms.

The Journal of antimicrobial chemotherapy

Avec: Sandra N Pinto , Susana A Dias , Ana F Cruz , Dalila Mil-Homens , Fabio Fernandes , Javier Valle , David Andreu , Manuel Prieto , Miguel A R B Castanho , Ana Coutinho , Ana Salomé Veiga

Fast NMR method to probe solvent accessibility and disordered regions in proteins.

Scientific reports

Avec: André F Faustino , Glauce M Barbosa , Micael Silva , Miguel A R B Castanho , Andrea T Da Poian , Eurico J Cabrita , Nuno C Santos , Fabio C L Almeida , Ivo C Martins

To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models.

Frontiers in bioengineering and biotechnology

Avec: Marco Cavaco , Clara Pérez-Peinado , Javier Valle , Rúben D M Silva , João D G Correia , David Andreu , Miguel A R B Castanho , Vera Neves

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.

Journal of medicinal chemistry

Avec: Maria Gallo , Estefanía Moreno , Sira Defaus , Antonio Ortega-Alvaro , Angel Gonzalez , Patricia Robledo , Marco Cavaco , Vera Neves , Miguel A R B Castanho , Vicent Casadó , Leonardo Pardo , Rafael Maldonado , David Andreu

Exosomes and Brain Metastases: A Review on Their Role and Potential Applications.

International journal of molecular sciences

Avec: Filipa D Oliveira , Miguel A R B Castanho , Vera Neves

The antimetastatic breast cancer activity of the viral protein-derived peptide vCPP2319 as revealed by cellular biomechanics.

The FEBS journal

Avec: Filipa D Oliveira , Marco Cavaco , Tiago N Figueira , Javier Valle , Vera Neves , David Andreu , Diana Gaspar , Miguel A R B Castanho

Parainfluenza Fusion Peptide Promotes Membrane Fusion by Assembling into Oligomeric Porelike Structures.

ACS chemical biology

Avec: Mariana Valério , Diogo A Mendonça , João Morais , Carolina C Buga , Carlos H Cruz , Miguel A R B Castanho , Manuel N Melo , Cláudio M Soares , Ana Salomé Veiga , Diana Lousa

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms.

The Journal of antimicrobial chemotherapy

Avec: Susana A Dias , Sandra N Pinto , Ana S Silva-Herdade , Olivier Cheneval , David J Craik , Ana Coutinho , Miguel A R B Castanho , Sónia T Henriques , Ana Salomé Veiga

Repurposing anti-cancer porphyrin derivative drugs to target SARS-CoV-2 envelope.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Diogo A Mendonça , Iris Cadima-Couto , Carolina C Buga , Zoe A Arnaut , Fabio A Schaberle , Luis G Arnaut , Miguel A R B Castanho , Christine Cruz-Oliveira

Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells.

ACS infectious diseases

Avec: Tiago N Figueira , Marco M Domingues , Françoise Illien , Iris Cadima-Couto , Toni Todorovski , David Andreu , Sandrine Sagan , Miguel A R B Castanho , Astrid Walrant , Ana Salomé Veiga

Réseau de co-auteurs

David Andreu 14 collaborations

Vera Neves 12 collaborations

Marco Cavaco 10 collaborations

Javier Valle 8 collaborations

Ana Salomé Veiga 8 collaborations

Susana A Dias 6 collaborations

Diana Gaspar 5 collaborations

Diogo A Mendonça 5 collaborations

Ana S Silva-Herdade 4 collaborations

Katia Conceição 4 collaborations

Tiago N Figueira 4 collaborations

João D G Correia 4 collaborations

Iris Cadima-Couto 4 collaborations

David Cordeiro Sousa 3 collaborations

Inês Leal 3 collaborations

Susana Moreira 3 collaborations

Sónia do Vale 3 collaborations

Patrícia Dionísio 3 collaborations

Luís Abegão Pinto 3 collaborations

Carlos Marques-Neves 3 collaborations

Manuel N Melo 3 collaborations

Sandra N Pinto 3 collaborations

Ana Coutinho 3 collaborations

Montserrat Heras 3 collaborations

Filipa D Oliveira 3 collaborations

Clara Pérez-Peinado 3 collaborations

Christine Cruz-Oliveira 3 collaborations

Sira Defaus 3 collaborations

Toni Todorovski 3 collaborations

Patrícia Fraga 2 collaborations

Erik Strandberg 2 collaborations

Parvesh Wadhwani 2 collaborations

Christian Mink 2 collaborations

Eduard Bardají 2 collaborations

Anne S Ulrich 2 collaborations

Beatriz Vieira-da-Silva 2 collaborations

Vitor Martins de Andrade 2 collaborations

Vasanthakumar G Ramu 2 collaborations

Julia Skalska 2 collaborations

Érica O Mello 2 collaborations

Valdirene M Gomes 2 collaborations

Sónia T Henriques 2 collaborations

Ana S Veiga 2 collaborations

Diana Lousa 2 collaborations

Cláudio M Soares 2 collaborations

Lurdes Gano 2 collaborations

Patrício Aguiar 2 collaborations

David J Craik 2 collaborations

Rúben D M Silva 2 collaborations

Andrea T Da Poian 2 collaborations

Carolina C Buga 2 collaborations

Ana R Silva-Herdade 1 collaboration

Jochen Bürck 1 collaboration

Patrick Anders 1 collaboration

Jonas van den Berg 1 collaboration

Raffaele A M Ciriello 1 collaboration

Jakob P Ulmschneider 1 collaboration

Luís Tavares 1 collaboration

Manuela Oliveira 1 collaboration

Juliana Campos Junqueira 1 collaboration

Jéssica Diane Dos Santos 1 collaboration

Grant McNaughton-Smith 1 collaboration

Vitor M Andrade 1 collaboration

Gabrielle L Cena 1 collaboration

Peta J Harvey 1 collaboration

Thais H Costa Petrin 1 collaboration

Valmir Fadel 1 collaboration

Danubia B Martins 1 collaboration

Ana Cruz 1 collaboration

Luciana Marciano Sergio 1 collaboration

Manoel Arcisio-Miranda 1 collaboration

Marcia P Dos Santos Cabrera 1 collaboration

Ana R Santa-Maria 1 collaboration

Fruzsina R Walter 1 collaboration

Sándor Valkai 1 collaboration

Ana Rita Brás 1 collaboration

Mária Mészáros 1 collaboration

András Kincses 1 collaboration

Adrián Klepe 1 collaboration

László Zimányi 1 collaboration

András Dér 1 collaboration

Mária A Deli 1 collaboration

Antónia R T Pinto 1 collaboration

Sara R R Campos 1 collaboration

António M Baptista 1 collaboration

Vitor M de Andrade 1 collaboration

Vitor D M de Oliveira 1 collaboration

Uilla Barcick 1 collaboration

Eduard R Bardají 1 collaboration

André Zelanis 1 collaboration

Aline Capella 1 collaboration

Juliana C Junqueira 1 collaboration

Ruben D M Silva 1 collaboration

Rita F Belo 1 collaboration

Margarida L F Martins 1 collaboration

Liana Shvachiy 1 collaboration

Tiago Costa-Coelho 1 collaboration

Carolina de Almeida-Borlido 1 collaboration

João Fonseca-Gomes 1 collaboration

Hugo Vicente Miranda 1 collaboration

Tiago F Outeiro 1 collaboration

Joana E Coelho 1 collaboration

Sara Xapelli 1 collaboration

Cláudia A Valente 1 collaboration

Eduard Bardaji 1 collaboration

Maria José Diógenes 1 collaboration

Ana M Sebastião 1 collaboration

Gabrielle L de Cena 1 collaboration

Verônica A da Silva 1 collaboration

Xisto Antonio de Oliveira Neto 1 collaboration

Dayane Batista Tada 1 collaboration

Michael Richardson 1 collaboration

Sonia A de Andrade 1 collaboration

Mônica Lopes-Ferreira 1 collaboration

Grégoire J-B Philippe 1 collaboration

Caibin Sheng 1 collaboration

Yen-Hua Huang 1 collaboration

Aurélie H Benfield 1 collaboration

Nicholas D Condon 1 collaboration

Joachim Weidmann 1 collaboration

Nicole Lawrence 1 collaboration

Alexander Löwer 1 collaboration

Sónia Troeira Henriques 1 collaboration

Alexandra Tauzin 1 collaboration

João M Freire 1 collaboration

Catarina Cunha-Santos 1 collaboration

Inês Bártolo 1 collaboration

Nuno Taveira 1 collaboration

Joao Goncalves 1 collaboration

Fabrizio Mammano 1 collaboration

Johannes Reichert 1 collaboration

Irene Wacker 1 collaboration

Mariët Bakker 1 collaboration

Maria Angeles Jiménez 1 collaboration

Lorena O Fernandes-Siqueira 1 collaboration

Giuseppina Guida 1 collaboration

Fernanda I V Limas 1 collaboration

Íris Cadima-Couto 1 collaboration

Ruben da Silva 1 collaboration

Ana F Cruz 1 collaboration

Dalila Mil-Homens 1 collaboration

Fabio Fernandes 1 collaboration

Manuel Prieto 1 collaboration

André F Faustino 1 collaboration

Glauce M Barbosa 1 collaboration

Micael Silva 1 collaboration

Eurico J Cabrita 1 collaboration

Nuno C Santos 1 collaboration

Fabio C L Almeida 1 collaboration

Ivo C Martins 1 collaboration

Maria Gallo 1 collaboration

Estefanía Moreno 1 collaboration

Antonio Ortega-Alvaro 1 collaboration

Angel Gonzalez 1 collaboration

Patricia Robledo 1 collaboration

Vicent Casadó 1 collaboration

Leonardo Pardo 1 collaboration

Rafael Maldonado 1 collaboration

Mariana Valério 1 collaboration

João Morais 1 collaboration

Carlos H Cruz 1 collaboration

Olivier Cheneval 1 collaboration

Zoe A Arnaut 1 collaboration

Fabio A Schaberle 1 collaboration

Luis G Arnaut 1 collaboration

Marco M Domingues 1 collaboration

Françoise Illien 1 collaboration

Sandrine Sagan 1 collaboration

Astrid Walrant 1 collaboration